Chemistries of bifunctional PROTAC degraders

C Cao, M He, L Wang, Y He, Y Rao - Chemical Society Reviews, 2022 - pubs.rsc.org
Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …

PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Active targeting of gold nanoparticles as cancer therapeutics

ZR Goddard, MJ Marín, DA Russell… - Chemical Society …, 2020 - pubs.rsc.org
Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their
biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug …

MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

W Bao, M Liu, J Meng, S Liu, S Wang, R Jia… - Nature …, 2021 - nature.com
Targeting subcellular organelle with multilevel damage has shown great promise for
antitumor therapy. Here, we report a core-shell type of nanoagent with iron (III) carboxylate …

[HTML][HTML] Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

H Mei, S Cai, D Huang, H Gao, J Cao, B He - Bioactive materials, 2022 - Elsevier
The considerable development of carrier-free nanodrugs has been achieved due to their
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …

Nanocarriers for drug delivery applications

M Chamundeeswari, J Jeslin, ML Verma - Environmental Chemistry …, 2019 - Springer
Nanobiotechnology research has recently provided numerous basic and applied advances
in the health sector. Nanocarriers have been developed for efficient drug delivery and …

[HTML][HTML] Biomacromolecules as carriers in drug delivery and tissue engineering

Y Zhang, T Sun, C Jiang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in
recent years because of their inherent biochemical and biophysical properties including …

Cancer nanomedicine: from targeted delivery to combination therapy

X Xu, W Ho, X Zhang, N Bertrand… - Trends in molecular …, 2015 - cell.com
The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of
various diseases, including cancer. The unique properties of nanoparticles (NPs), such as …

[HTML][HTML] Targeting folate receptor alpha for cancer treatment

A Cheung, HJ Bax, DH Josephs, KM Ilieva… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

GM Van Dam, G Themelis, LMA Crane, NJ Harlaar… - Nature medicine, 2011 - nature.com
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific
intraoperative fluorescence imaging may improve staging and debulking efforts in …