Chemistries of bifunctional PROTAC degraders
C Cao, M He, L Wang, Y He, Y Rao - Chemical Society Reviews, 2022 - pubs.rsc.org
Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
Active targeting of gold nanoparticles as cancer therapeutics
ZR Goddard, MJ Marín, DA Russell… - Chemical Society …, 2020 - pubs.rsc.org
Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their
biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug …
biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug …
MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
W Bao, M Liu, J Meng, S Liu, S Wang, R Jia… - Nature …, 2021 - nature.com
Targeting subcellular organelle with multilevel damage has shown great promise for
antitumor therapy. Here, we report a core-shell type of nanoagent with iron (III) carboxylate …
antitumor therapy. Here, we report a core-shell type of nanoagent with iron (III) carboxylate …
[HTML][HTML] Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
The considerable development of carrier-free nanodrugs has been achieved due to their
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …
Nanocarriers for drug delivery applications
M Chamundeeswari, J Jeslin, ML Verma - Environmental Chemistry …, 2019 - Springer
Nanobiotechnology research has recently provided numerous basic and applied advances
in the health sector. Nanocarriers have been developed for efficient drug delivery and …
in the health sector. Nanocarriers have been developed for efficient drug delivery and …
[HTML][HTML] Biomacromolecules as carriers in drug delivery and tissue engineering
Y Zhang, T Sun, C Jiang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in
recent years because of their inherent biochemical and biophysical properties including …
recent years because of their inherent biochemical and biophysical properties including …
Cancer nanomedicine: from targeted delivery to combination therapy
The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of
various diseases, including cancer. The unique properties of nanoparticles (NPs), such as …
various diseases, including cancer. The unique properties of nanoparticles (NPs), such as …
[HTML][HTML] Targeting folate receptor alpha for cancer treatment
Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …
advancements in our understanding of molecular pathways that underpin cancer …
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
GM Van Dam, G Themelis, LMA Crane, NJ Harlaar… - Nature medicine, 2011 - nature.com
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific
intraoperative fluorescence imaging may improve staging and debulking efforts in …
intraoperative fluorescence imaging may improve staging and debulking efforts in …