Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

Amino acids are indispensable for the growth of cancer cells. This includes essential amino
acids, the carbon skeleton of which cannot be synthesized, and conditionally essential …

Glutamate is the primary excitatory neurotransmitter in the mammalian brain. Glutamatergic
neurotransmission may be modulated at multiple levels, only a minority of which are …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
traditional models of schizophrenia have emphasized dopaminergic dysfunction. over the …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the
vertebrate central nervous system. The effective synaptic concentrations of glycine are …

Background: Based on the glutamatergic NMDA receptor hypofunction theory of
schizophrenia, NMDA receptor modulators (NMDARMs) may have therapeutic potential in …

Rationale Activation of “co-agonist” N-methyl-d-aspartate (NMDA) and Glycine B sites is
mandatory for the operation of NMDA receptors, which play an important role in the control …

Wayne Fenton was a major driving force behind the establishment of the Measurement and
Treatment Research to Improve Cognition in Schizophrenia (MATRICS) and Treatment Units …

Noncompetitive N-methyl-D-aspartate (NMDA) blockers induce schizophrenic-like
symptoms in humans, presumably by impairing glutamatergic transmission. Therefore, a …