Recently, it was shown that hepatocyte DNA synthesis after partial hepatectomy (PH) is
impaired in interleukin‐6–deficient (IL‐6−/−) mice, which results in significantly delayed, but …

Phenobarbital was the first tumor promoter for rodent liver to be associated with the 2-stage
or initiation-promotion concept of carcinogenesis. In rats and mice preinitiated with …

Abstract M6P/IGF2R imprinting first appeared approximately 150 million years ago following
the divergence of prototherian from therian mammals. Although M6P/IGF2R is clearly …

Background/Aims: Hepatitis B and C viruses, two inducers of hepatocarcinomas, have been
shown to activate AP-1, NF-kappaB and STAT in vitro, but no detailed information on the …

We performed gene expression profiling of normal and hepatocellular carcinoma (HCC)
liver tissues using a high-density microarray that contained 3,063 human cDNA. The results …

Astragalus membranaceus (AM) has been widely used for treating liver diseases in
traditional Chinese medicine. Experimental evidence indicates that it has antitumor …

Hepatocellular carcinoma (HCC) is one of the major causes of human cancer deaths
worldwide. To identify alterations of the genetic program associated with human HCC, we …

Triterpenoids are implicated in the chemoprevention of various cancers. Current challenge
is to define the molecular mechanism underlying the chemopreventive activity of …

We have previously shown that inactivation of mannose 6-phosphate/insulin-like growth
factor 2 receptor (M6P/IGF2R) is a common early event in both human liver and breast …

Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated
regarding the relationship between reactive oxygen species, antioxidant enzyme expression …