Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial
impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and …

The importance of gut microbiota in health and disease is being highlighted by numerous
research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke …

Type 2 diabetes mellitus (T2DM) is a worldwide major health burden and heart failure (HF)
is the most common cardiovascular (CV) complication in affected patients. Therefore …

It has become widely accepted that inflammation is a driving force behind a variety of
chronic diseases, such as cardiovascular disease, diabetes, kidney disease, cancer …

Doxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of
cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Aim We tested the hypothesis that metformin may regress left ventricular hypertrophy (LVH)
in patients who have coronary artery disease (CAD), with insulin resistance (IR) and/or pre …

Metformin has been in clinical use for the management of type 2 diabetes for more than 60
years and is supported by a vast database of clinical experience: this includes evidence for …