Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Objectives To determine by how much statins reduce serum concentrations of low density
lipoprotein (LDL) cholesterol and incidence of ischaemic heart disease (IHD) events and …

Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Statins are the treatment of choice for the management of hypercholesterolaemia because of
their proven efficacy and safety profile. They also have an increasing role in managing …

Hypercholesterolaemia is a risk factor for the development of atherosclerotic disease.
Atorvastatin lowers plasma low-density lipoprotein (LDL) cholesterol levels by inhibition of …

Synopsis Atorvastatin is a synthetic HMG-CoA reductase inhibitor which lowers plasma
cholesterol levels by inhibiting endogenous cholesterol synthesis. It also reduces …

Importance Observational studies have reported that statin use may be associated with
improved outcomes of various infections. Ventilator-associated pneumonia (VAP) is the most …

Background Emerging epidemiological evidence suggests that statin use may reduce the
risk of infections and infection-related complications. Our objective was to examine the …

Background: Ezetimibe (SCH 58235) is a novel cholesterol absorption inhibitor that
selectively and potently blocks intestinal absorption of dietary and biliary cholesterol …

The basic helix-loop-helix-PAS transcription factor (CLOCK, Circadian locomotor output
cycles protein kaput) was discovered in 1994 as a circadian clock. Soon after its discovery …