Background: Ezetimibe, a first-in-its-class inhibitor of cholesterol absorption, is an effective
agent for combined use with statins to achieve low-density lipoprotein cholesterol (LDL-C) …

Low levels of high-density lipoprotein cholesterol (HDL-C) are currently considered to be a
major risk factor for the development of coronary artery disease (CAD). Deficiencies in the …

Atorvastatin (ATS) is the gold-standard treatment worldwide for the management of
hypercholesterolemia and prevention of cardiovascular diseases associated with …

Ferumoxtran-10 is an ultrasmall superparamagnetic iron oxide nanoparticle potentially
useful as a contrast material in magnetic resonance imaging for the diagnosis of …

MATERIALS AND METHODS Data Source The plasma rosuvastatin and MVA
concentrations reported by Martin et al. 8) were used as the source of PK/PD modeling data …

Recent studies have documented the long-term impact of 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase inhibitors on mortality and morbidity related to coronary …

In recent years, advances in pharmaceutical processing technologies have resulted in
development of medicines that provide therapeutic pharmacokinetic exposure for a period …

Methods. This study received prior approval from the Marshfield Clinic Institutional Review
Board. The study was conducted in accordance with the basic Principles of the Declaration …

Objective: To determine the effects of cimetidine on the steady-state pharmacokinetics and
pharmacodynamics of atorvastatin, a 3-hydroxymethylglutaryl coenzyme A (HMG-CoA) …

The Marshfield Clinic Personalized Medicine Research Project (PMRP) represents a large
population‐based biobank located in central Wisconsin. To position the PMRP database for …