Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

Background Cardiorespiratory fitness (CRF) is inversely associated with all-cause mortality.
However, the association of CRF and mortality risk for different races, women, and elderly …

Background The association between cardiorespiratory fitness (CRF) and mortality risk is
based mostly on 1 CRF assessment. The impact of CRF change on mortality risk is not well …

Endurance training is associated with increased cardiorespiratory fitness (CRF) and
decreased risk of cardiovascular disease (CVD). However, a causal relationship between …

Humans have a larger energy budget than great apes, allowing the combination of the
metabolically expensive traits that define our life history. This budget is ultimately related to …

The distinct functions and phenotypes of human tissues and cells derive from the activity of
biological processes that varies in a context-dependent manner. Here, we present the …

Most sports nutrition guidelines are based on group average responses and professional
opinion. Precision nutrition for athletes aims to improve the individualization of nutrition …

Aims Preventive strategies for heart failure with preserved ejection fraction (HFpEF) include
pharmacotherapies and lifestyle modifications. However, the association between …