Chordoma: current status, problems, and future directions

MF Wedekind, BC Widemann, G Cote - Current Problems in Cancer, 2021 - Elsevier
Chordoma is a rare tumor that occurs along the axial spine in pediatrics and adults, with an
incidence of approximately 350 cases per year in the United States. While typically …

The potential role of miR‐1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco‐suppressor microRNA?

MR Kalhori, M Soleimani, E Arefian… - Journal of cellular …, 2022 - Wiley Online Library
Cancer is one of the leading causes of death in humans because of the lack of early
diagnosis, distant metastases, and the resistance to adjuvant therapies, including …

Personalized chordoma organoids for drug discovery studies

A Al Shihabi, A Davarifar, HTL Nguyen, N Tavanaie… - Science …, 2022 - science.org
Chordomas are rare tumors of notochordal origin, most commonly arising in the sacrum or
skull base. Chordomas are considered insensitive to conventional chemotherapy, and their …

DNA methylation-based prognostic subtypes of chordoma tumors in tissue and plasma

JA Zuccato, V Patil, S Mansouri, JC Liu… - Neuro …, 2022 - academic.oup.com
Background Chordomas are rare malignant bone cancers of the skull-base and spine.
Patient survival is variable and not reliably predicted using clinical factors or molecular …

[HTML][HTML] B7-H3 as a target for CAR-T cell therapy in skull base chordoma

C Long, G Li, C Zhang, T Jiang, Y Li, X Duan… - Frontiers in …, 2021 - frontiersin.org
Objective: chordomas are rare bone tumors with few therapeutic options. Skull base and
sacrum are the two most common origin sites. Immunotherapies are emerging as the most …

[HTML][HTML] Trends in tumor site-specific survival of bone sarcomas from 1980 to 2018: a surveillance, epidemiology and end results-based study

X Hu, K Deng, H Ye, Z Sun, W Huang, Y Sun, W Yan - Cancers, 2021 - mdpi.com
Simple Summary Bone sarcomas are rare cancers coming from the mesenchyme cells of the
body skeletal system. Osteosarcoma, chondrosarcoma, Ewing sarcoma, and chordoma are …

Targeted delivery of cancer drug paclitaxel to chordomas tumor cells via an RNA nanoparticle harboring an EGFR aptamer

D Xiao, Y Huang, S Huang, J Zhuang, P Chen… - Colloids and Surfaces B …, 2022 - Elsevier
Paclitaxel has been extensively used in clinics for cancer treatment. However, its limited
solubility in aqueous solution and high occurrence of side effects have also been widely …

Chordomas: a review with emphasis on their pathophysiology, pathology, molecular biology, and genetics

G Karpathiou, JM Dumollard, M Dridi, P Dal Col… - … -Research and Practice, 2020 - Elsevier
Chordomas are uncommon, bone, axial, or (rarely) extra-axial tumors that are malignant and
frequently recur but less commonly metastasize. They usually affect adults, with a very small …

[HTML][HTML] Chordoma: A Comprehensive Systematic Review of Clinical Trials

S Chen, R Ulloa, J Soffer, RJ Alcazar-Felix… - Cancers, 2023 - mdpi.com
Simple Summary Surgery is the primary treatment for chordoma. However, residual or
recurrent chordoma presents a significant problem for clinicians. The aim of this work is to …

[HTML][HTML] Multivariate analysis and validation of the prognostic factors for skull base chordoma

C Teng, Q Yang, Z Xiong, N Ye, X Li - Frontiers in Surgery, 2021 - frontiersin.org
Background: Skull base chordoma is a rare tumor with low-grade malignancy and a high
recurrence rate, the factors affecting the prognosis of patients need to be further studied. For …