Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …

Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for
repair. How targeting is achieved and the DNA repair pathways involved in this process …

The evolution of the nucleus, the defining feature of eukaryotic cells, was long shrouded in
speculation and mystery. There is now strong evidence that nuclear pore complexes (NPCs) …

During mitosis, the nuclear pore complex is disassembled and, increasingly, nucleoporins
are proving to have mitotic functions when released from the pore. We find a contribution of …

Small GTP-binding proteins exist in eukaryotes from yeast to animals to plants and constitute
a superfamily whose members function as molecular switches that cycle between “active” …

The nuclear pore complex (NPC) facilitates the trafficking of proteins and RNA between the
nucleus and cytoplasm. The role of nucleoporins (Nups) in transport in the context of the …

Die Lamina ist ein Netzwerk aus Lamin-Proteinen und befindet sich unterhalb der inneren
Kernmembran. Die Lamine A/C, die zu den Typ V Intermediärfilamenten gehören, spielen …

In die Kernmembran von Eukaryoten sind Kernporenkomplexe eingelagert. Diese stellen
die einzige Verbindung zwischen dem Nukleo-und Zytoplasma dar und vermitteln den …