Autologous haematopoietic stem cell transplantation (AHSCT) is a multistep procedure that
enables destruction of the immune system and its reconstitution from haematopoietic stem …

Some patients with severe systemic lupus erythematosus do not respond to conventional
immunosuppression or suffer severe side effects from such treatment. In order to explore the …

Objective: To analyse the durability of the responses after haematopoietic stem cell
transplantation (HSCT) for severe systemic sclerosis (SSc) and determine whether the high …

Intractable autoimmune diseases in chimeric resistant MRL/lpr mice were treated by a new
bone marrow transplantation (BMT) method consisting of fractionated irradiation, 5.5 Gy× 2 …

Background & Aims: Remission of several autoimmune diseases has been described after
allogeneic marrow transplantation. The aim of this study was to determine if the natural …

Haematological complications are frequently seen in SLE. Anaemia, leucopenias and
thrombocytopenia may result from bone marrow failure or excessive peripheral cell …

Multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis are immune-
mediated diseases that are responsive to suppression or modulation of the immune system …

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to B
and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models …

Background: Immunoablative high-dose cyclophosphamide without stem-cell rescue
induces durable, complete remission in most patients with aplastic anemia. Objective: To …

Objective Evidence from animal studies, case reports, and phase I studies suggests that
hemopoietic stem cell transplantation (HSCT) can be effective in the treatment of rheumatoid …