Methods to determine and analyze the cellular spatial distribution extracted from multiplex immunofluorescence data to understand the tumor microenvironment

ER Parra - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Image analysis using multiplex immunofluorescence (mIF) to detect different proteins in a
single tissue section has revolutionized immunohistochemical methods in recent years. With …

A quantitative modelling approach to zebrafish pigment pattern formation

JP Owen, RN Kelsh, CA Yates - Elife, 2020 - elifesciences.org
Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped
pattern generated through the self-organisation of three different chromatophores …

Quantification of spatial and phenotypic heterogeneity in an agent-based model of tumour-macrophage interactions

JA Bull, HM Byrne - PLOS Computational Biology, 2023 - journals.plos.org
We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The
wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial …

Integrating digital pathology and mathematical modelling to predict spatial biomarker dynamics in cancer immunotherapy

LG Hutchinson, O Grimm - NPJ Digital Medicine, 2022 - nature.com
In oncology clinical trials, on-treatment biopsy samples are taken to confirm the mode of
action of new molecules, among other reasons. Yet, the time point of sample collection is …

A data driven approach for cross-slip modelling in continuum dislocation dynamics

V Vivekanandan, B Anglin, A El-Azab - International Journal of Plasticity, 2023 - Elsevier
Cross-slip is a thermally activated process by which screw dislocation changes its glide
plane to another slip plane sharing the same Burgers vector. The rate at which this process …

Patterns of oncogene coexpression at single-cell resolution influence survival in lymphoma

MM Hoppe, P Jaynes, F Shuangyi, Y Peng, S Sridhar… - Cancer discovery, 2023 - AACR
Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if
combinations of oncogenes in cellular subpopulations within a cancer influence clinical …

Self-organization of ferroelectric domains induced by water and reinforced via ultrasonic vibration

S Yan, X Hu, X Lu, J Zhang, X Shen… - Communications …, 2023 - nature.com
Pattern formation caused by self-organization is a fascinating phenomenon that appears in
biological, chemical, and physical systems. In ferroelectrics, although a variety of domain …

Packing density, homogeneity, and regularity: Quantitative correlations between topology and thermoresponsive morphology of PNIPAM-co-PAA microgel coatings

C Cutright, Z Brotherton, L Alexander, J Harris… - Applied Surface …, 2020 - Elsevier
This study investigates the formation of monolayers of microgel particles comprising poly [(N-
isopropylacrylamide)-co-(acrylic acid)] on solid substrates, their surface morphology, and …

Inference of glioblastoma migration and proliferation rates using single time-point images

E Rosén, HB Mangukiya, L Elfineh… - Communications …, 2023 - nature.com
Cancer cell migration is a driving mechanism of invasion in solid malignant tumors. Anti-
migratory treatments provide an alternative approach for managing disease progression …

Detection and characterization of chemotaxis without cell tracking

JD Hywood, G Rice, SV Pageon… - Journal of the Royal …, 2021 - royalsocietypublishing.org
Swarming has been observed in various biological systems from collective animal
movements to immune cells. In the cellular context, swarming is driven by the secretion of …