Methods to determine and analyze the cellular spatial distribution extracted from multiplex immunofluorescence data to understand the tumor microenvironment
ER Parra - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Image analysis using multiplex immunofluorescence (mIF) to detect different proteins in a
single tissue section has revolutionized immunohistochemical methods in recent years. With …
single tissue section has revolutionized immunohistochemical methods in recent years. With …
A quantitative modelling approach to zebrafish pigment pattern formation
Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped
pattern generated through the self-organisation of three different chromatophores …
pattern generated through the self-organisation of three different chromatophores …
Quantification of spatial and phenotypic heterogeneity in an agent-based model of tumour-macrophage interactions
We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The
wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial …
wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial …
Integrating digital pathology and mathematical modelling to predict spatial biomarker dynamics in cancer immunotherapy
LG Hutchinson, O Grimm - NPJ Digital Medicine, 2022 - nature.com
In oncology clinical trials, on-treatment biopsy samples are taken to confirm the mode of
action of new molecules, among other reasons. Yet, the time point of sample collection is …
action of new molecules, among other reasons. Yet, the time point of sample collection is …
A data driven approach for cross-slip modelling in continuum dislocation dynamics
V Vivekanandan, B Anglin, A El-Azab - International Journal of Plasticity, 2023 - Elsevier
Cross-slip is a thermally activated process by which screw dislocation changes its glide
plane to another slip plane sharing the same Burgers vector. The rate at which this process …
plane to another slip plane sharing the same Burgers vector. The rate at which this process …
Patterns of oncogene coexpression at single-cell resolution influence survival in lymphoma
MM Hoppe, P Jaynes, F Shuangyi, Y Peng, S Sridhar… - Cancer discovery, 2023 - AACR
Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if
combinations of oncogenes in cellular subpopulations within a cancer influence clinical …
combinations of oncogenes in cellular subpopulations within a cancer influence clinical …
Self-organization of ferroelectric domains induced by water and reinforced via ultrasonic vibration
S Yan, X Hu, X Lu, J Zhang, X Shen… - Communications …, 2023 - nature.com
Pattern formation caused by self-organization is a fascinating phenomenon that appears in
biological, chemical, and physical systems. In ferroelectrics, although a variety of domain …
biological, chemical, and physical systems. In ferroelectrics, although a variety of domain …
Packing density, homogeneity, and regularity: Quantitative correlations between topology and thermoresponsive morphology of PNIPAM-co-PAA microgel coatings
C Cutright, Z Brotherton, L Alexander, J Harris… - Applied Surface …, 2020 - Elsevier
This study investigates the formation of monolayers of microgel particles comprising poly [(N-
isopropylacrylamide)-co-(acrylic acid)] on solid substrates, their surface morphology, and …
isopropylacrylamide)-co-(acrylic acid)] on solid substrates, their surface morphology, and …
Inference of glioblastoma migration and proliferation rates using single time-point images
E Rosén, HB Mangukiya, L Elfineh… - Communications …, 2023 - nature.com
Cancer cell migration is a driving mechanism of invasion in solid malignant tumors. Anti-
migratory treatments provide an alternative approach for managing disease progression …
migratory treatments provide an alternative approach for managing disease progression …
Detection and characterization of chemotaxis without cell tracking
Swarming has been observed in various biological systems from collective animal
movements to immune cells. In the cellular context, swarming is driven by the secretion of …
movements to immune cells. In the cellular context, swarming is driven by the secretion of …