Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer
agents are major challenges for cancer treatment, which energizes medicinal chemists to …

Currently, heterocycles have occupied an important position in the fields of drug design.
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …

4-Aryl-3-thiocyanatobutan-2-ones were prepared by Meerwein reactions from methyl vinyl
ketone and aryldiazonium salts under copper (II) catalysis in 35–75% yields. α-Thiocyanato …

In the present study, new 2-phenyl-5, 6, 7, 8-tetrahydroimidazo [1, 2-b] pyridazines bearing
sulfonamides were synthesized, characterized and evaluated for their anticancer activities …

The structure, tautomerization pathways, vibrational spectra, and photochemistry of 2-amino-
4-methylthiazole (AMT) molecule were studied by matrix isolation FTIR spectroscopy and …

A one-pot cascade strategy for the synthesis of 2-aminothiazole derivatives by tertiary
enaminones, KSCN, and anilines was developed. By changing the reaction temperature, the …

A variety of novel tryptanthrin aminothiazole analogues 3a‐h and 5a‐h possessing a
biologically active thiazole moiety were synthesized by the reaction of tryptanthrin …

Highly fluorinated candidates containing anticancer pharmacophores like
thiosemicarbazone (5a–e) and its cyclic analogues hydrazineylidenethiazolidine (6a–e), 2 …

A series of novel hybrid compounds containing benzofuroxan and 2-aminothiazole moieties
are synthesized via aromatic nucleophilic substitution reaction. Possible reaction pathways …

The present study reports the synthesis of sulphonamide-azaheterocycle conjugates (3 aj)
and evaluates its in vitro anticancer activity against breast cancer cell line (MCF-7) and liver …