It has been 50 years since Francis Fontan pioneered the operation that today bears his
name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a …

The Fontan procedure has led to increased long-term survival of patients with single
ventricle congenital heart disease. Hemodynamic changes associated with the Fontan …

Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and …

This study demonstrates high mortality following a diagnosis of HCC in patients undergoing
a Fontan operation that is comparable to the< 50% 1-year survival among patients with HCC …

Fontan-associated liver disease is a hepatic disorder arising from hemodynamic changes
and systemic venous congestion following Fontan surgery. The histological changes …

Congestive hepatopathy (CH) arises from chronically elevated right‐sided heart pressures
transmitted to the liver by passive venous congestion. Over time, CH can lead to hepatic …

Congestive hepatopathy (CH) arises from chronically elevated right‐sided heart pressures
transmitted to the liver by passive venous congestion. Over time, CH can lead to hepatic …

Aim Fontan surgery is often the procedure of choice for patients with congenital single
effective ventricle. In the long term, elevated systemic venous pressure and chronic ischemia …

Background & Aims Fontan surgery is used to treat a variety of congenital heart
malformations, and may lead to advanced chronic liver disease in the long-term. This study …

The Fontan operation is a lifesaving procedure for patients with functional single-ventricle
congenital heart disease, where hypoplastic left heart syndrome is the most frequent …