Prediction of CYP‐mediated DDIs involving inhibition: approaches to address the requirements for system qualification of the Simcyp simulator
PJ Kilford, KF Chen, K Crewe, I Gardner… - CPT …, 2022 - Wiley Online Library
Physiologically‐based pharmacokinetic (PBPK) modeling is being increasingly used in drug
development to avoid unnecessary clinical drug–drug interaction (DDI) studies and inform …
development to avoid unnecessary clinical drug–drug interaction (DDI) studies and inform …
Mrna-based nanomedicinal products to address corneal inflammation by interleukin-10 supplementation
I Gómez-Aguado, J Rodríguez-Castejón… - Pharmaceutics, 2021 - mdpi.com
The anti-inflammatory cytokine Interleukin-10 (IL-10) is considered an efficient treatment for
corneal inflammation, in spite of its short half-life and poor eye bioavailability. In the present …
corneal inflammation, in spite of its short half-life and poor eye bioavailability. In the present …
Electroanalysis of 4′-hydroxydiclofenac for CYP2C9 enzymatic assay
AV Kuzikov, TA Filippova, RA Masamrekh… - Electrocatalysis, 2022 - Springer
In this work, we have investigated the electrochemical properties of 4′-hydroxydiclofenac,
which is the main product of cytochrome P450 2C9 (CYP2C9)-dependent metabolism of a …
which is the main product of cytochrome P450 2C9 (CYP2C9)-dependent metabolism of a …
A comparative systematic analysis of the influence of microplastics on colon cells, mouse and colon organoids
SB Park, WH Jung, KJ Choi, B Koh, KY Kim - Tissue engineering and …, 2023 - Springer
Abstract Background: Microplastics (MPs) are small fragments from any type of plastic
formed from various sources, including plastic waste and microfibers from clothing. MPs …
formed from various sources, including plastic waste and microfibers from clothing. MPs …
Recent Studies of Artificial Intelligence on In Silico Drug Absorption
Absorption is an important area of research in pharmacochemistry and drug development,
because the drug has to be absorbed before any drug effects can occur. Furthermore, the …
because the drug has to be absorbed before any drug effects can occur. Furthermore, the …
The in silico and in vitro analysis of donepezil derivatives for Anopheles acetylcholinesterase inhibition
TA Rants'o, DG van Greunen, CJ van der Westhuizen… - Plos one, 2022 - journals.plos.org
Current studies on Anopheles anticholinesterase insecticides are focusing on identifying
agents with high selectivity towards Anopheles over mammalian targets …
agents with high selectivity towards Anopheles over mammalian targets …
Characterization of herpetrione amorphous nanoparticles stabilized by hydroxypropylmethyl cellulose and its absorption mechanism in vitro
F Wang, L Hang, B Dai, F Li, Y Zhu, H Jia, Y Ai… - International Journal of …, 2024 - Elsevier
Herpetrione (HPE) is an effective compound that has been used in the treatment of liver
diseases. To improve its dissolution and absorption, herpetrione nanosuspensions was …
diseases. To improve its dissolution and absorption, herpetrione nanosuspensions was …
[HTML][HTML] Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism
L Cai, L Xu, K Shen, Q Wang, R Ni, X Xu… - Journal of Traditional and …, 2024 - Elsevier
STRP1, a polysaccharide active ingredient isolated from the traditional Chinese medicine
Sophorae tonkinensis radix, has demonstrated a protective effect against acetaminophen …
Sophorae tonkinensis radix, has demonstrated a protective effect against acetaminophen …
Revisiting cyp2c9-mediated drug-drug interactions: A review
NA Mutalib, MAAM Rafi, NA Latip - Research Journal of …, 2021 - indianjournals.com
Drug-drug interactions (DDI) are the most common cases that occur in our healthcare in
which are very alarming as it may lead to severe complications. Consumption of natural …
which are very alarming as it may lead to severe complications. Consumption of natural …