The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …

Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its
clinical features are the proliferation of joint synovial tissue, the formation of pannus and the …

Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are
essential for germinal center formation, affinity maturation, and the development of most high …

Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

Although T cell help for B cells was described several decades ago, it was the identification
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of …

The interplay between effector T cells and regulatory T cells (Treg cells) is crucial for
adaptive immunity, but how Treg cells control diverse effector responses is elusive. We …