Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …
Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 …
A Belal, NM Abdel Gawad, ABM Mehany… - Journal of enzyme …, 2022 - Taylor & Francis
A new series of 1 H-pyrrole (6a–c, 8a–c), pyrrolo [3, 2-d] pyrimidines (9a–c) and pyrrolo [3, 2-
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives via Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors
Microbial DNA gyrase is regarded as an outstanding microbial target. Hence, 15 new
quinoline derivatives (5–14) were designed and synthesized. The antimicrobial activity of …
quinoline derivatives (5–14) were designed and synthesized. The antimicrobial activity of …
[HTML][HTML] Cardioprotective effect of 2-methoxy phenol derivatives against oxidative stress-induced vascular complications: an integrated in vitro, in silico, and in vivo …
Background Oxidative stress and inflammation play crucial roles in macro/microvascular
complications. Phenolic compounds and their derivatives show promise as therapeutic …
complications. Phenolic compounds and their derivatives show promise as therapeutic …
Thieno[2,3-b]thiophene Derivatives as Potential EGFRWT and EGFRT790M Inhibitors with Antioxidant Activities: Microwave-Assisted Synthesis and Quantitative In …
SA Ahmed, MS Kamel, MO Aboelez, X Ma… - ACS …, 2022 - ACS Publications
Microwave-assisted synthesis and spectral analysis of certain novel derivatives of 3, 4-
diaminothieno [2, 3-b] thiophene-2, 5-dicarbonitrile 1–7 were carried out. Compounds 1–7 …
diaminothieno [2, 3-b] thiophene-2, 5-dicarbonitrile 1–7 were carried out. Compounds 1–7 …
Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol …
Aims Nephrotoxicity is one of the most serious health consequences of cadmium (Cd) toxic
exposure. Cd was associated with nephrotoxicity through different mechanisms including …
exposure. Cd was associated with nephrotoxicity through different mechanisms including …
Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and …
EA Madbouly, ESM Lashine, AA Al-Karmalawy… - New Journal of …, 2022 - pubs.rsc.org
A new series of thirty-one quinazolinone–chalcone hybrid molecules 13–43 were designed,
synthesized, and structurally characterized by different spectroscopic techniques. All the …
synthesized, and structurally characterized by different spectroscopic techniques. All the …
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as …
MF El-Behairy, WH Abd-Allah, MM Khalifa… - Journal of Enzyme …, 2023 - Taylor & Francis
In this research, two novel series of dibenzo [b, f] azepines (14 candidates) were designed
and synthesised based on the rigidification principle and following the reported …
and synthesised based on the rigidification principle and following the reported …
Metformin ameliorates doxorubicin-induced cardiotoxicity targeting HMGB1/TLR4/NLRP3 signaling pathway in mice
Aims Oxidative stress and inflammation have been linked to doxorubicin (DOX)-induced
cardiotoxicity, while the exact molecular processes are currently under investigation. The …
cardiotoxicity, while the exact molecular processes are currently under investigation. The …