Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

Trial watch: chemotherapy-induced immunogenic cell death in oncology

J Sprooten, RS Laureano, I Vanmeerbeek… - …, 2023 - Taylor & Francis
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

Synergistic reinforcing of immunogenic cell death and transforming tumor‐associated macrophages via a multifunctional cascade bioreactor for optimizing cancer …

C Huang, B Lin, C Chen, H Wang, X Lin… - Advanced …, 2022 - Wiley Online Library
Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct
a tumor microenvironment and activate antitumor immunity. This study proposes a two‐way …

Microneedle patch integrated with porous silicon confined dual nanozymes for synergistic and hyperthermia‐enhanced nanocatalytic ferroptosis treatment of …

J Zhao, W Duan, X Liu, F Xi, J Wu - Advanced Functional …, 2023 - Wiley Online Library
Superficial melanoma is the deadliest form of skin cancer without desirable clinically
therapeutic options. Nanozymes, artificial nanomaterials with physicochemical performance …

Marine‐Derived Hydrogels for Biomedical Applications

X Lin, J Wang, X Wu, Y Luo, Y Wang… - Advanced Functional …, 2023 - Wiley Online Library
Marine organisms provide novel and broad sources for the preparations and applications of
biomaterials. Since the urgent requirement of bio‐hydrogels to mimic tissue extracellular …

Research progress of microneedles in the treatment of melanoma

X Li, Z Zhao, M Zhang, G Ling, P Zhang - Journal of controlled release, 2022 - Elsevier
Melanoma is an aggressive malignancy deriving from melanocytes, which is characterized
by high tendency of metastases and mortality rate. Current therapies for melanoma, like …

Highly sensitive and reliable internal-standard surface-enhanced Raman scattering microneedles for determination of bacterial metabolites as infection biomarkers in …

R Mei, Y Wang, S Shi, X Zhao, Z Zhang… - Analytical …, 2022 - ACS Publications
Microneedles (MNs) are currently one of the most promising tools for skin interstitial fluid
(ISF)-based biosensing, while it is still a challenge to expand the detectable biomarkers in …

[HTML][HTML] Polysaccharide-based transdermal drug delivery

J Li, H Xiang, Q Zhang, X Miao - Pharmaceuticals, 2022 - mdpi.com
Materials derived from natural plants and animals have great potential for transdermal drug
delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources …

Steerable microneedles enabling deep delivery of photosensitizers and CRISPR/Cas9 systems for effective combination cancer therapy

T Wang, G Chen, S Zhang, D Li, G Wei, X Zhao… - Nano Letters, 2023 - ACS Publications
Although gene therapy has shown prospects in treating triple-negative breast cancer, it is
insufficient to treat such a malignant tumor. Herein, nanoparticles (NPs)-embedded …

Photothermal and acid-responsive Fucoidan-CuS bubble pump microneedles for combined CDT/PTT/CT treatment of melanoma

J Tao, B Wang, Y Dong, XY Chen, S Li… - … Applied Materials & …, 2023 - ACS Publications
Transdermal cancer therapy faces great challenges in clinical practice due to the low drug
transdermal efficiency and the unsatisfactory effect of monotherapy. Herein, we develop a …