The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Conspectus SARS-CoV-2 is the etiological pathogen of the COVID-19 pandemic, which led
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …

To discover new drugs to combat COVID-19, an understanding of the molecular basis of
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …

Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Abstract The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-
19 therapy, given its likely druggability and essentiality in the viral maturation and replication …

Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Abstract Interleukin-6 (IL-6) is a multi-tasking cytokine that represents high activity in patients
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cancer. High …

Vaccines have reduced the transmission and severity of COVID‐19, but there remains a
paucity of efficacious treatment for drug‐resistant strains and more susceptible individuals …

Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants
being observed around the globe new therapeutics, particularly direct-acting antivirals that …