Here, we show that the capacity to manufacture IL-2 identifies constituents of the expanded
CD8 T cell effector pool that display stem-like features, preferentially survive, rapidly attain …

T‐bet and Eomes are T‐box transcription factors that drive the differentiation and function of
cytotoxic lymphocytes such as NK cells. Their DNA‐binding domains are highly similar …

Although natural killer (NK) cells are classified as innate immune cells, recent studies
demonstrate that NK cells can become long-lived memory cells and contribute to secondary …

Inhibitory signaling in dysfunctional CD8 T cells through the programmed cell death 1 (PD-1)
axis is well established in chronic viral infections and cancers. PD-1 is also transiently …

New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …

Nuclear factor of activated T cells (NFAT) proteins are Ca2+-regulated transcription factors
that control gene expression in many cell types. NFAT proteins are heavily phosphorylated …

Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …

Memory CD8+ T cells induced upon immunization exhibit improved functional features that
contribute to protection of immunized hosts. Although both cognate antigen recognition and …

Abstract Follicular helper CD4 T (Tfh) cells are a distinct type of differentiated CD4 T cells
uniquely specialized for B cell help. In this study, we examined Tfh cell fate commitment …

Cancer immunotherapies under development have generally focused on either stimulating T
cell immunity or driving antibody-directed effector functions of the innate immune system …