Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …

The beneficial effect of ACE inhibitors in hypertension and heart failure may relate, at least in
part, to their capacity to interfere with bradykinin metabolism. In addition, recent studies have …

Objective Mannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such
binding contributes to renin/prorenin clearance but not to angiotensin generation. Here, we …

Background—Angiotensin (Ang) II type 2 (AT2) receptor stimulation results in coronary
vasodilation in the rat heart. In contrast, AT2 receptor–mediated vasodilation could not be …

We studied here the independent roles of angiotensin II and aldosterone in regulating the
sodium chloride cotransporter (NCC) of the distal convoluted tubule. We adrenalectomized …

During hypovolemia and hyperkalemia, the kidneys defend homeostasis by Na+ retention
and K+ secretion, respectively. Aldosterone mediates both effects, but it is unclear how the …

INTRODUCTION: The beneficial effects of ACE inhibitors are generally ascribed to blockade
of neurohormonal activation. However, especially in chronic heart failure (CHF) patients …

We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various
animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis …

Renin-angiotensin systems may mediate cardiovascular disease pathogenesis through a
balance of actions of angiotensin II on (potentially proatherogenic) constitutive type 1 (AT1R) …

Background—The mechanisms behind the beneficial effects of renin-angiotensin system
blockade after myocardial infarction (MI) are not fully elucidated but may include interference …