[HTML][HTML] Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: potential therapeutic impacts

AP Daiwile, S Jayanthi, JL Cadet - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Methamphetamine (METH) use, and misuse are associated with severe socioeconomic
consequences. METH users develop tolerance, lose control over drug taking behaviors, and …

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

YH Chen, J Yang, H Wu, KT Beier, M Sawan - Frontiers in Psychiatry, 2023 - frontiersin.org
Achieving abstinence from drugs is a long journey and can be particularly challenging in the
case of methamphetamine, which has a higher relapse rate than other drugs. Therefore, real …

Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood–brain barrier damage after methamphetamine exposure: involving the …

J Huang, J Ding, X Wang, C Gu, Y He, Y Li… - Brain, Behavior, and …, 2022 - Elsevier
The α-synuclein (α-syn) is involved in methamphetamine (METH)-induced neurotoxicity.
Neurons can transfer excessive α-syn to neighboring neurons and glial cells. The effects of α …

Neuron–Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity

J Bravo, I Ribeiro, AF Terceiro, EB Andrade… - Cells, 2022 - mdpi.com
Exposure to methamphetamine (Meth) has been classically associated with damage to
neuronal terminals. However, it is now becoming clear that addiction may also result from …

Amphetamines in child medicine: a review of ClinicalTrials. gov

SO Alalalmeh, OE Hegazi, M Shahwan… - Frontiers in …, 2023 - frontiersin.org
Background: Globally, the use of amphetamines as therapeutic agents in pediatric medicine
is a crucial area of concern, especially given the population's vulnerability. Methods: On 6 …

Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells

A Gopinath, T Riaz, E Miller, L Phan… - Basic & clinical …, 2023 - Wiley Online Library
Methamphetamine is a widely abused psychostimulant and one of the main targets of
dopamine transporter (DAT). Methamphetamine reduces DAT‐mediated dopamine uptake …

Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 …

B Garmabi, R Mohaddes, F Rezvani, F Mohseni… - Journal of Chemical …, 2022 - Elsevier
Objective Methamphetamine (METH) is one of the most widely used addictive drugs, and
addiction to it is on the rise all over the world. METH abuse has long-term damaging effects …

Sex-dependent alterations in the mRNA expression of enzymes involved in dopamine synthesis and breakdown after methamphetamine self-administration

AE Miller, AP Daiwile, JL Cadet - Neurotoxicity Research, 2022 - Springer
Sex differences have been reported in methamphetamine (METH) use disorder in humans
and in animal models of METH exposure. Specifically, animals that self-administer METH …

Dynamic immune and exosome transcriptomic responses in patients undergoing psychostimulant methamphetamine withdrawal

H Wu, Z Zhang, Y Ma, F Chen, P Xiong, Z Xie… - Frontiers in Cellular …, 2022 - frontiersin.org
Methamphetamine (METH) addiction and withdrawal cause serious harm to both the
immune system and nervous system. However, the pathogenesis remains largely unknown …

Neonatal brain inflammation enhances methamphetamine-induced reinstated behavioral sensitization in adult rats analyzed with explainable machine learning

KC Wang, NB Ojeda, H Wang, HS Chiang… - Neurochemistry …, 2024 - Elsevier
Neonatal brain inflammation produced by intraperitoneal (ip) injection of lipopolysaccharide
(LPS) results in long-lasting brain dopaminergic injury and motor disturbances in adult rats …