Oxidative stress, a condition characterized by an imbalance between pro-oxidant molecules
and antioxidant defense systems, is increasingly recognized as a key contributor to cancer …

Glutathione transferase classical GSH conjugation activity plays a critical role in cellular
detoxification against xenobiotics and noxious compounds as well as against oxidative …

In humans, the glutathione S-transferases (GST) protein family is composed of seven
members that present remarkable structural similarity and some degree of overlapping …

There are numerous extra-and intra-cellular processes involved in the production of reactive
oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules …

In humans, the cytosolic glutathione S-transferase (GST) family of proteins is encoded by 16
genes presented in seven different classes. GSTs exhibit remarkable structural similarity …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are …

Reactive oxygen species (ROS) are produced by living organisms as a result of normal
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …