BDNF signaling in context: From synaptic regulation to psychiatric disorders

CS Wang, ET Kavalali, LM Monteggia - Cell, 2022 - cell.com
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Neurotrophin regulation of neural circuit development and function

H Park, M Poo - Nature Reviews Neuroscience, 2013 - nature.com
Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

Brain‐derived neurotrophic factor and the development of structural neuronal connectivity

S Cohen‐Cory, AH Kidane, NJ Shirkey… - Developmental …, 2010 - Wiley Online Library
During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

[HTML][HTML] Enhancement of learning and memory by elevating brain magnesium

I Slutsky, N Abumaria, LJ Wu, C Huang, L Zhang, B Li… - Neuron, 2010 - cell.com
Learning and memory are fundamental brain functions affected by dietary and
environmental factors. Here, we show that increasing brain magnesium using a newly …

Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support

SE Marsh, M Blurton-Jones - Neurochemistry international, 2017 - Elsevier
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease currently affect tens of millions of people worldwide. Unfortunately, as …

The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents

YK Jeon, CH Ha - Environmental health and preventive medicine, 2017 - Springer
Background Brain derived neurotrophic factor (BDNF) seems to serve as an important
regulatory mechanism in the growth and development of neurons in many areas of the brain …

Host microbiota modulates development of social preference in mice

T Arentsen, H Raith, Y Qian, H Forssberg… - Microbial ecology in …, 2015 - Taylor & Francis
Background Mounting evidence indicates that the indigenous gut microbiota exerts long-
lasting programming effects on brain function and behaviour. Objective In this study, we …

Neurodevelopment, GABA system dysfunction, and schizophrenia

MJ Schmidt, K Mirnics - Neuropsychopharmacology, 2015 - nature.com
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …

ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons

M Alonso, JH Medina, L Pozzo-Miller - Learning & memory, 2004 - learnmem.cshlp.org
Brain-derived neurotrophic factor (BDNF) is a potent modulator of synaptic transmission and
plasticity in the CNS, acting both pre-and postsynaptically. We demonstrated recently that …

BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses

K Gottmann, T Mittmann, V Lessmann - Experimental brain research, 2009 - Springer
In the past 15 years numerous reports provided strong evidence that brain-derived
neurotrophic factor (BDNF) is one of the most important modulators of glutamatergic and …