[HTML][HTML] Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy

A Mafi, M Rezaee, N Hedayati, SD Hogan… - Cell Communication and …, 2023 - Springer
Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

[HTML][HTML] Therapeutic algorithm for use of melatonin in patients with COVID-19

RJ Reiter, P Abreu-Gonzalez, PE Marik… - Frontiers in …, 2020 - frontiersin.org
The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of
thousands of individuals worldwide. This highly infectious condition continues to ravage the …

[HTML][HTML] Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway

BI Arioz, B Tastan, E Tarakcioglu, KU Tufekci… - Frontiers in …, 2019 - frontiersin.org
Inflammation is a crucial component of various stress-induced responses that contributes to
the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is …

Melatonin: another avenue for treating osteoporosis?

T Li, S Jiang, C Lu, W Yang, Z Yang… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy

M Mirza-Aghazadeh-Attari, EM Ekrami, SAM Aghdas… - Life sciences, 2020 - Elsevier
Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …

The role of melatonin, a multitasking molecule, in retarding the processes of ageing

M Majidinia, RJ Reiter, SK Shakouri, B Yousefi - Ageing Research Reviews, 2018 - Elsevier
Biological ageing is generally accompanied by a gradual loss of cellular functions and
physiological integrity of organ systems, the consequential enhancement of vulnerability …

[HTML][HTML] Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in …

HL Zhu, XT Shi, XF Xu, GX Zhou, YW Xiong, SJ Yi… - Redox Biology, 2021 - Elsevier
Gestational exposure to environmental stress induces fetal growth restriction (FGR), and
thereby increasing the risk of infant death and chronic noncommunicable diseases in adults …

[HTML][HTML] Insight into the roles of melatonin in bone tissue and bone‑related diseases

X Lu, S Yu, G Chen, W Zheng… - International …, 2021 - spandidos-publications.com
Bone‑related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis

SG Darband, S Sadighparvar, B Yousefi, M Kaviani… - Life Sciences, 2020 - Elsevier
Accumulating recent studies have demonstrated the preventive and therapeutic effects of
polyphonic compounds such as quercetin in colorectal cancer. Therefore, we aimed to …

Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men

O Stefani, M Freyburger, S Veitz… - Journal of Pineal …, 2021 - Wiley Online Library
We examined whether dynamically changing light across a scheduled 16‐h waking day
influences sleepiness, cognitive performance, visual comfort, melatonin secretion, and sleep …