The gold complex auranofin: new perspectives for cancer therapy
FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …
to the lack of long-term treatment options following the standard form of care. New options …
Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer
To understand the mechanism of acquired resistance to poly (ADP-ribose) polymerase
inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells …
inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells …
Antiprogestins in breast cancer treatment: are we ready?
CLM Lanari, V Wargon, PA Rojas, A Molinolo - 2012 - ri.conicet.gov.ar
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer
death in females worldwide. It is accepted that breast cancer is not a single disease, but …
death in females worldwide. It is accepted that breast cancer is not a single disease, but …
Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats
L Zhang, Y Li, YC Dong, CY Guan, S Tian, XD Lv… - Scientific Reports, 2022 - nature.com
The endometrium plays a critical role in embryo implantation and pregnancy, and a thin
uterus is recognized as a key factor in embryo implantation failure. Umbilical cord …
uterus is recognized as a key factor in embryo implantation failure. Umbilical cord …
[HTML][HTML] Mifepristone suppresses basal triple-negative breast cancer stem cells by down-regulating KLF5 expression
Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast
cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for …
cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for …
GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome
DC West, D Pan, EY Tonsing-Carter… - Molecular Cancer …, 2016 - AACR
In estrogen receptor (ER)–negative breast cancer, high tumor glucocorticoid receptor (GR)
expression has been associated with a relatively poor outcome. In contrast, using a meta …
expression has been associated with a relatively poor outcome. In contrast, using a meta …
Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells
FH Abdalbari, E Martinez-Jaramillo, BN Forgie, E Tran… - Cancers, 2023 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the most prevalent type of
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …
Discovery of a glucocorticoid receptor (GR) activity signature using selective GR antagonism in ER-negative breast cancer
DC West, M Kocherginsky, EY Tonsing-Carter… - Clinical Cancer …, 2018 - AACR
Purpose: Although high glucocorticoid receptor (GR) expression in early-stage estrogen
receptor (ER)-negative breast cancer is associated with shortened relapse-free survival …
receptor (ER)-negative breast cancer is associated with shortened relapse-free survival …
Guanidine-modified cyclometalated iridium (III) complexes for mitochondria-targeted imaging and photodynamic therapy
XD Song, BB Chen, SF He, NL Pan, JX Liao… - European Journal of …, 2019 - Elsevier
PDT is a well-established therapeutic modality for many types of cancer. Photoluminescent
cyclometalated iridium (III) complexes are one of the most commonly used classes of …
cyclometalated iridium (III) complexes are one of the most commonly used classes of …
Synthesis, RNA-sequence and evaluation of anticancer efficacy of ruthenium (II) polypyridyl complexes toward HepG2 cells
H Hu, H Zhang, R Zhong, Y Yang, C Huang… - Journal of Inorganic …, 2023 - Elsevier
In this article, four new Ru (II) complexes [Ru (dmbpy) 2 (TFBIP)](PF 6) 2 (dmbpy= 4, 4′-
dimethyl-2, 2′-bipyridine, TFPIP= 2-(4′-trifluoromethyl)-[1, 1′-biphenyl]-4-yl)-1H-imidazo …
dimethyl-2, 2′-bipyridine, TFPIP= 2-(4′-trifluoromethyl)-[1, 1′-biphenyl]-4-yl)-1H-imidazo …