Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Osteosarcoma (OS), the most common malignant tumor in the musculoskeletal system,
mainly occurs in adolescents. OS results in high mortality and disability rates due to a fatal …

Background: We designed the study to investigate whether methotrexate, doxorubicin, and
cisplatinum (MAP) chemotherapy strategy was still the preferred option for the survival of …

Recent clinical trials have shown that adaptive drug therapies can be more efficient than a
standard cancer treatment based on a continuous use of maximum tolerated doses (MTD) …

PURPOSE Platinum-resistant oral cancer has a dismal outcome with limited treatment
options. We conducted a phase I/II study to identify the optimal biologic dose (OBD) of …

Osteosarcoma (OS) is the most severe bone malignant tumor, responsible for altered
osteoid deposition and with a high rate of metastasis. It is characterized by heterogeneity …

In most clinical trials, thiazolidinediones do not show any relevant anti-cancer activity when
used as mono-therapy. Clinical inefficacy contrasts ambiguous pre-clinical data either …

Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by
Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect - PMC Back to Top …

Background/Aims: Increasing evidences suggest that dysregulated expression of miRNAs
contributes to the progression of various tumors. However, the underlying function of miR …

Long noncoding RNAs (lncRNAs) were identified as a vital part in the development and
progression of cancer in recent years. Colorectal neoplasia differentially expressed …