P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
Pharmaceutical formulations with P-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …
Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges
Increasing life expectancy has led to an aging population, which has consequently
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …
Liposomes for the treatment of brain cancer—A review
Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes
are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate …
are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate …
Nanoparticle-based drug delivery systems to overcome gastric cancer drug resistance
Gastric cancer (GC) results from deregulated cell growth in the stomach. Despite significant
efforts and recent advancements in the treatment of gastric cancer, it remains a life …
efforts and recent advancements in the treatment of gastric cancer, it remains a life …
Brain microvascular endothelial cells and blood-brain barrier dysfunction in psychotic disorders
Although there is convergent evidence for blood-brain barrier (BBB) dysfunction and
peripheral inflammation in schizophrenia (SZ) and bipolar disorder (BD), it is unknown …
peripheral inflammation in schizophrenia (SZ) and bipolar disorder (BD), it is unknown …
Cannabinoids, blood–brain barrier, and brain disposition
F Calapai, L Cardia, EE Sorbara, M Navarra… - Pharmaceutics, 2020 - mdpi.com
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory …
cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory …
Chitosan-based nanoparticles of targeted drug delivery system in breast cancer treatment
Breast cancer remains one of the world's most dangerous diseases because of the difficulty
of finding cost-effective and specific targets for effective and efficient treatment methods. The …
of finding cost-effective and specific targets for effective and efficient treatment methods. The …
Oral peptide delivery: Challenges and the way ahead
Highlights•Oral route of administration is the preferred route for drug delivery.•Dosage form
designing plays an essential role in oral peptide delivery.•Preclinical and clinical aspects of …
designing plays an essential role in oral peptide delivery.•Preclinical and clinical aspects of …
The role of polysaccharides from natural resources to design oral insulin micro-and nanoparticles intended for the treatment of Diabetes mellitus: A review
AB Meneguin, ALP Silvestre, L Sposito… - Carbohydrate …, 2021 - Elsevier
Oral administration of insulin (INS) would represent a revolution in the treatment of diabetes,
considering that this route mimics the physiological dynamics of endogenous INS. Nano-and …
considering that this route mimics the physiological dynamics of endogenous INS. Nano-and …