Background Orphan medicines show some characteristics that hinder the evaluation of their
clinical added value. The often low level of evidence available for orphan drugs, together …

The Ogoniland region of the Niger Delta contains a vast number of sites contaminated with
petroleum hydrocarbons that originated from Nigeria's active oil sector. The United Nations …

Quality adjusted life years (QALYs) offer a measure of value which is advantageous for
health technology appraisal (HTA). As a composite measure, combining length of life and …

Importance The cost-effectiveness of different surgical techniques for radical prostatectomy
remains a subject of debate. Emergence of recent critical clinical data and changes in …

Abstract The Emergency Department (ED) plays a key role in restoring the health of patients.
Ensuring the availability of the ED and achieving rational use of its resources is critical to …

Background In recent years, the potential of multi-criteria decision analysis (MCDA) in the
health field has been discussed widely. However, most MCDA methodologies have given …

Objective: Optimizing multicomponent behavioral and biobehavioral interventions presents
a complex decision problem. To arrive at an intervention that is both effective and readily …

Health economists are increasingly interested in integrated care in order to support decision-
makers to find cost-effective solutions able to tackle the threat that chronic diseases pose on …

In this study, we applied graph theory to clinical decision-making for Stress Urinary
Incontinence (SUI) treatment. Utilizing discrete mathematics, we developed a system to …

Background Integrating patient preferences in Health Technology Assessment (HTA) is
argued to improve uptake, adherence, and patient satisfaction. However, how to elicit and …