During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …

While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of
conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor …

IgG antibodies are key effector molecules in acquired immunity to Plasmodium falciparum
malaria, and the PfEMP1 adhesins expressed on the surface of the infected erythrocytes are …

The response of gamma delta (γδ) T cells in the acute versus chronic phases of the same
infection is unclear. How γδ T cells function in acute Mycobacterium tuberculosis (Mtb) …

Summary γδ T cells are generally considered innate-like lymphocytes, however, an"
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Human CD1a is a non-polymorphic glycoprotein that presents lipid antigens to T cells. The
most obvious role of CD1a is associated with its expression on Langerhans cells in …

γδ T cells support the immunological control of viral infections, in particular during
cytomegalovirus (CMV) reactivation in immunocompromised patients after allogeneic …

Understanding immune mechanisms that mediate malaria protection is critical for improving
vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum …

Epstein-Barr Virus (EBV) is a human gamma herpes virus, which causes several diseases in
immunocompetent (mononucleosis, chronic fatigue syndrome, gastric cancer, endemic …