Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Intercellular communication was long thought to be regulated exclusively through direct
contact between cells or via release of soluble molecules that transmit the signal by binding …

The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase
(MAPK) signalling pathway regulates many cellular functions, including proliferation …

A cycloparaphenylene can be thought of as the shortest possible cross section of an
armchair carbon nanotube. Although envisioned decades ago, these molecules—also …

Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected
diversity in the mechanisms of their activation by growth factor ligands. Strategies for …

Antibody-drug conjugate (ADC) which delivers cytotoxic drugs specifically into targeted cells
through internalization and lysosomal trafficking has emerged as an effective cancer …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

How the epidermal growth factor receptor (EGFR) activates is incompletely understood. The
intracellular portion of the receptor is intrinsically active in solution, and to study its …

Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …