[HTML][HTML] Significant risk of graft-versus-host disease with exposure to checkpoint inhibitors before and after allogeneic transplantation

A Ijaz, AY Khan, SU Malik, W Faridi, MA Fraz… - Biology of Blood and …, 2019 - Elsevier
Investigators are using checkpoint inhibitors (CPIs) to treat aggressive hematologic
malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo …

Cytokines and costimulation in acute graft-versus-host disease

GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

Impaired T-and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide

B Rambaldi, HT Kim, C Reynolds… - Blood …, 2021 - ashpublications.org
Administration of posttransplant cyclophosphamide (PTCy) has significantly expanded the
number of patients undergoing HLA-haploidentical hematopoietic cell transplantation (haplo …

Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma

RW Merryman, L Castagna, L Giordano, VT Ho… - Leukemia, 2021 - nature.com
Anti-PD-1 monoclonal antibodies yield high response rates in patients with
relapsed/refractory classic Hodgkin lymphoma (cHL), but most patients will eventually …

Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT

H Senjo, S Harada, SI Kubota, Y Tanaka, T Tateno… - Blood, 2023 - ashpublications.org
Calcineurin inhibitor–based graft-versus-host disease (GVHD) prophylaxis is standard in
allogeneic hematopoietic stem cell transplantation (HCT) but fails to induce long-term …

Improved outcomes for relapsed/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents

MA Spinner, RA Sica, JS Tamaresis… - Blood, The Journal …, 2023 - ashpublications.org
The treatment landscape of relapsed/refractory (R/R) classic Hodgkin lymphoma (cHL) has
evolved significantly over the past decade after the approval of brentuximab vedotin (BV) …

Autologous stem cell transplantation after anti-PD-1 therapy for multiply relapsed or refractory Hodgkin lymphoma

RW Merryman, RA Redd, T Nishihori, J Chavez… - Blood …, 2021 - ashpublications.org
Autologous stem cell transplantation (ASCT) can be curative for patients with
relapsed/refractory Hodgkin lymphoma (HL). Based on studies suggesting that anti-PD-1 …

[HTML][HTML] Lower graft-versus-host disease and relapse risk in post-transplant cyclophosphamide–based haploidentical versus matched sibling donor reduced-intensity …

S Ahmed, JA Kanakry, KW Ahn, C Litovich… - Biology of blood and …, 2019 - Elsevier
Classic Hodgkin lymphoma (cHL) patients with relapsed or refractory disease may benefit
from allogeneic hematopoietic cell transplantation (allo-HCT), but many lack a matched …

Single-center phase 2 study of PD-1 inhibitor combined with DNA hypomethylation agent+ CAG regimen in patients with relapsed/refractory acute myeloid leukemia

XN Gao, YF Su, M Li, Y Jing, J Wang, L Xu… - Cancer Immunology …, 2023 - Springer
Anti-PD-1 monotherapy had limited clinical efficacy in relapsed/refractory (r/r) AML patients
with higher PD-1 and PD-L1 expression. Hence, we investigated the efficacy and safety of …

Optimizing outcomes in relapsed/refractory Hodgkin lymphoma: a review of current and forthcoming therapeutic strategies

TP Vassilakopoulos… - Therapeutic …, 2020 - journals.sagepub.com
The outcome of patients with relapsed/refractory classical Hodgkin lymphoma (rr-cHL) has
improved considerably in recent years owing to the approval of highly active novel agents …