The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Calcium is an important signaling molecule involved in the regulation of many cellular
functions. The large free energy in the Ca2+ ion membrane gradients makes Ca2+ signaling …

An increased flux through glycolysis supports the proliferation of cancer cells by providing
additional energy in the form of ATP as well as glucose-derived metabolic intermediates for …

Stimulation of mitochondrial oxidative metabolism by Ca2+ is now generally recognised as
important for the control of cellular ATP homeostasis. Here, we review the mechanisms …

Mitochondrial Ca2+ transport was initially considered important only in buffering of cytosolic
Ca2+ by acting as a “sink” under conditions of Ca2+ overload. The main regulator of ATP …

The hallmarks of cancer capture the most essential phenotypic characteristics of malignant
transformation and progression. Although numerous factors involved in this multi-step …

Fatty acids represent a very important, if not the most important, substrate for myocardial
energy metabolism. The heart derives fatty acids from circulating FFA bound to albumin and …

Consumption of adenosine triphosphate (ATP) by the heart can change dramatically as the
energetic demands increase from a period of rest to strenuous activity. Mitochondrial ATP …

The cell is capable of maintaining a steady-state flux of energy from mitochondrial oxidative
phosphorylation, producing ATP, to the cytosolic adenosinetriphosphatases (ATPases) …

RS Balaban. Cardiac Energy Metabolism Homeotasis: Role of Cytosolic Calcium. Journal of
Molecular and Cellular Cardiology (2002) 34, 1259–1271. The heart is capable of …