Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

Self‐organized microvascular networks (MVNs) have become key to the development of
many microphysiological models. However, the self‐organizing nature of this process …

Tissue engineering is an emerging means for resolving the problems of tissue repair and
organ replacement in regenerative medicine. Insufficient supply of nutrients and oxygen to …

Although various types of organs-on-chips have been introduced recently as tools for drug
discovery, the current studies are limited in terms of fabrication methods. The fabrication …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …

Microfluidic cell cultures are ideally positioned to become the next generation of in vitro
diagnostic tools for biomedical research, where key biological processes such as cell …

Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …