A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
[HTML][HTML] A microfluidic platform integrating functional vascularized organoids-on-chip
The development of vascular networks in microfluidic chips is crucial for the long-term
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …
[HTML][HTML] Advanced in vitro models of vascular biology: human induced pluripotent stem cells and organ-on-chip technology
The vascular system is one of the first to develop during embryogenesis and is essential for
all organs and tissues in our body to develop and function. It has many essential roles …
all organs and tissues in our body to develop and function. It has many essential roles …
Vascularization in tissue engineering: fundamentals and state-of-art
Vascularization is among the top challenges that impede the clinical application of
engineered tissues. This challenge has spurred tremendous research endeavor, defined as …
engineered tissues. This challenge has spurred tremendous research endeavor, defined as …
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment
D Kim, KS Hwang, EU Seo, S Seo… - Advanced …, 2022 - Wiley Online Library
The tumor microenvironment (TME) is the environment around the tumor, including blood
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …
Development of a functional airway-on-a-chip by 3D cell printing
We used 3D cell printing to emulate an airway coupled with a naturally-derived blood vessel
network in vitro. Decellularized extracellular matrix bioink derived from porcine tracheal …
network in vitro. Decellularized extracellular matrix bioink derived from porcine tracheal …
Control of perfusable microvascular network morphology using a multiculture microfluidic system
The mechanical and biochemical microenvironment influences the morphological
characteristics of microvascular networks (MVNs) formed by endothelial cells (ECs) …
characteristics of microvascular networks (MVNs) formed by endothelial cells (ECs) …
Organs-on-a-chip: a new tool for drug discovery
Introduction: The development of emerging in vitro tissue culture platforms can be useful for
predicting human response to new compounds, which has been traditionally challenging in …
predicting human response to new compounds, which has been traditionally challenging in …
3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro
The human central nervous system (CNS) vasculature expresses a distinctive barrier
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …