Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Ex vivo lung perfusion (EVLP) is a data-intensive platform used for the assessment of
isolated lungs outside the body for transplantation; however, the integration of artificial …

Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …

Abstract Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to
inflammatory, metabolic, and oxidative stressors. We previously reported that myeloid SIRT1 …

Long-time ischemia worsening transplant outcomes in vascularized composite
allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an …

The modern era of organ transplantation was pioneered at the Peter Bent Brigham Hospital
in Boston by physician-scientists John P. Merrill (nephrologist), and Joseph E. Murray …

Inflammation is crucial to tumorigenesis and the development of metastasis. Hepatic
ischemia/reperfusion injury (IRI) is an unresolved problem in liver resection and …

BACKGROUND: Organ waste is a major cause of the donor liver shortage. Roughly 67% of
recovered organ donors have liver utilization annually. A new technology called …

Dynamic preservation methods such as normothermic, subnormothermic, and hypothermic
machine perfusion circuits have emerged as viable alternatives to conventional static cold …