The role of neutrophil extracellular traps in acute lung injury
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …
morbidity and mortality. Neutrophils play a key role in the development of different forms of …
Ischemia and reperfusion injury in kidney transplantation: relevant mechanisms in injury and repair
GJ Nieuwenhuijs-Moeke, SE Pischke… - Journal of clinical …, 2020 - mdpi.com
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …
inevitable in kidney transplantation and one of the most important mechanisms for non-or …
Sepsis pathophysiology, chronic critical illness, and persistent inflammation-immunosuppression and catabolism syndrome
JC Mira, LF Gentile, BJ Mathias, PA Efron… - Critical care …, 2017 - journals.lww.com
Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …
The interplay of reactive oxygen species, hypoxia, inflammation, and sirtuins in cancer initiation and progression
M Tafani, L Sansone, F Limana… - Oxidative medicine …, 2016 - Wiley Online Library
The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …
concentration and compartmentation determine their physiological or pathological effects …
Chronic critical illness and the persistent inflammation, immunosuppression, and catabolism syndrome
Dysregulated host immune responses to infection often occur, leading to sepsis, multiple
organ failure, and death. Some patients rapidly recover from sepsis, but many develop …
organ failure, and death. Some patients rapidly recover from sepsis, but many develop …
Persistent inflammation, immunosuppression and catabolism syndrome
JC Mira, SC Brakenridge, LL Moldawer… - Critical care …, 2017 - criticalcare.theclinics.com
Multiple organ failure (MOF) has plagued surgical intensive care units (ICUs) for more than
four decades, and its epidemiology has evolved because advances in care have allowed …
four decades, and its epidemiology has evolved because advances in care have allowed …
Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers
Severe sepsis represents a common, expensive, and deadly health care issue with limited
therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis …
therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis …
Dysregulated immunity and immunotherapy after sepsis
DB Darden, LS Kelly, BP Fenner, LL Moldawer… - Journal of clinical …, 2021 - mdpi.com
Implementation of protocolized surveillance, diagnosis, and management of septic patients,
and of surgical sepsis patients in particular, is shown to result in significantly increased …
and of surgical sepsis patients in particular, is shown to result in significantly increased …
The emerging role of ferroptosis in sepsis
Y Liu, S Tan, Y Wu, S Tan - DNA and cell biology, 2022 - liebertpub.com
Ferroptosis is a novel form of cell death characterized by the iron-dependent accumulation
of lipid peroxides and is different from other types of cell death. The mechanisms of …
of lipid peroxides and is different from other types of cell death. The mechanisms of …
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury
JL Martin, AV Gruszczyk, TE Beach, MP Murphy… - Pediatric …, 2019 - Springer
Acute kidney injury (AKI) remains a major problem in critically unwell children and young
adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a …
adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a …