[HTML][HTML] Significance of levocarnitine treatment in dialysis patients

H Takashima, T Maruyama, M Abe - Nutrients, 2021 - mdpi.com
Carnitine is a naturally occurring amino acid derivative that is involved in the transport of
long-chain fatty acids to the mitochondrial matrix. There, these substrates undergo β …

[HTML][HTML] The role of L-carnitine in kidney disease and related metabolic dysfunctions

T Ulinski, M Cirulli, MA Virmani - Kidney and Dialysis, 2023 - mdpi.com
Kidney disease is associated with a wide variety of metabolic abnormalities that accompany
the uremic state and the state of dialysis dependence. These include altered L-carnitine …

The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment

A Takahashi - Physiological Reports, 2021 - Wiley Online Library
Leg cramping is a common side effect of hemodialysis, and this is frequently treated by the
administration of carnitine, but this is not effective in every patient. Alkalosis is a key …

Evaluation of the relationship between serum carnitine levels and intradialytic complications in children with kidney failure

B Bazargani, SY Mojtahedi, D Fahimi, F Askarian… - Pediatric …, 2022 - Springer
Background Carnitine plays a crucial role in the metabolism of fatty acids as well as energy
production. Previous research has suggested a significant decrease in carnitine levels in …

[HTML][HTML] Prevalence of carnitine deficiency and decreased carnitine levels in patients on peritoneal dialysis

S Shimizu, H Takashima, R Tei, T Furukawa… - Nutrients, 2019 - mdpi.com
Background: Carnitine deficiency is common in patients on dialysis. Serum free carnitine
concentration is significantly lower in patients on hemodialysis (HD) than in healthy …

Carnitine supplements for people with chronic kidney disease requiring dialysis

N Nishioka, Y Luo, T Taniguchi… - Cochrane Database …, 2022 - cochranelibrary.com
Background Carnitine deficiency is common in patients with chronic kidney disease (CKD)
who require dialysis. Several clinical studies have suggested that carnitine supplementation …

Carnitine deficiency in intensive care unit patients undergoing continuous renal replacement therapy: a single-center retrospective study

M Oi, T Maruhashi, Y Asari - JMA journal, 2024 - jstage.jst.go.jp
Introduction: Carnitine deficiency is common in patients undergoing intermittent
hemodialysis and may also occur during continuous renal replacement therapy (CRRT). We …

[HTML][HTML] Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

Y Wang, J Yang, Y Zhang, J Zhou - International Journal of Molecular …, 2024 - mdpi.com
The function of the respiratory chain is closely associated with kidney function, and the
dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney …

[HTML][HTML] Pathophysiological roles of the serum acylcarnitine level and acylcarnitine/free carnitine ratio in patients with cardiovascular diseases

T Nakajima, T Fukuda, I Shibasaki, S Obi… - IJC Heart & …, 2024 - Elsevier
Introduction L-carnitine exerts protective effects, such as maintaining mitochondrial functions
and decreasing reactive oxygen species, while acylcarnitine (AC) is linked to the …

Association between carnitine deficiency and the erythropoietin resistance index in patients undergoing peritoneal dialysis: a cross-sectional observational study

S Kaneko, K Hirai, J Morino, S Minato, K Yanai… - Renal …, 2020 - Taylor & Francis
Carnitine deficiency contributes to developing various pathological conditions, such as
cardiac dysfunction, muscle weakness, and erythropoietin-resistant anemia in patients …