Vast potential exists for the development of novel, engineered platforms that manipulate
biology for the production of programmed advanced materials. Such systems would possess …

Organoids form through self-organization processes in which initially homogeneous
populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern …

A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …

Bioengineering can address many important needs, from transformative biomedicine to
environmental remediation. In addition to practical applications, the construction of new …

Natural biological materials exhibit remarkable properties: self-assembly from simple raw
materials, precise control of morphology, diverse physical and chemical properties, self …

Intracellular environments are heterogeneous milieus comprised of macromolecules,
osmolytes, and a range of assemblies that include membrane-bound organelles and …

Synthetic multicellular systems hold promise as models for understanding natural
development of biofilms and higher organisms and as tools for engineering complex multi …

Breakthroughs in precision cell surface engineering tools are supporting the rapid
development of programmable living assemblies with valuable features for tackling complex …

Turing patterns (TPs) underlie many fundamental developmental processes, but they
operate over narrow parameter ranges, raising the conundrum of how evolution can ever …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …