Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Obesity and the risk of cardiometabolic diseases

PL Valenzuela, P Carrera-Bastos… - Nature reviews …, 2023 - nature.com
The prevalence of obesity has reached pandemic proportions, and now approximately 25%
of adults in Westernized countries have obesity. Recognized as a major health concern …

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

I AlZaim, LPMH de Rooij, BN Sheikh… - Nature Reviews …, 2023 - nature.com
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

Spatiotemporal modulated scaffold for endogenous bone regeneration via harnessing sequentially released guiding signals

X Wang, W Dai, C Gao, L Zhang, Z Wan… - … Applied Materials & …, 2023 - ACS Publications
The design of a scaffold that can regulate the sequential differentiation of bone marrow
mesenchymal stromal cells (BMSCs) according to the endochondral ossification (ECO) …

Diabetes mellitus, energy metabolism, and COVID-19

C Conte, E Cipponeri, M Roden - Endocrine Reviews, 2024 - academic.oup.com
Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …

[HTML][HTML] New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets

YC Lin, YC Hou, HC Wang, YS Shan - Theranostics, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which
is due to delayed diagnosis and resistance to current therapies. The interactions between …

The modes of angiogenesis: An updated perspective

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
Following the process of vasculogenesis during development, angiogenesis generates new
vascular structures through a variety of different mechanisms or modes. These different …

Obesity and renal cell carcinoma: biological mechanisms and perspectives

N Venkatesh, A Martini, JL McQuade, P Msaouel… - Seminars in cancer …, 2023 - Elsevier
Obesity, defined by body mass index (BMI), is an established risk factor for specific renal cell
carcinoma (RCC) subtypes such as clear cell RCC, the most common RCC histology. Many …

White adipose tissue dysfunction: pathophysiology and emergent measurements

N Santillana, C Astudillo-Guerrero, A D'Espessailles… - Nutrients, 2023 - mdpi.com
White adipose tissue (AT) dysfunction plays an important role in the development of
cardiometabolic alterations associated with obesity. AT dysfunction is characterized by the …

Adipocyte glucocorticoid receptor activation with high glucocorticoid doses impairs healthy adipose tissue expansion by repressing angiogenesis

A Vali, H Dalle, A Loubaresse, J Gilleron, E Havis… - Diabetes, 2024 - Am Diabetes Assoc
In humans, glucocorticoids (GCs) are commonly prescribed because of their anti-
inflammatory and immunosuppressive properties. However, high doses of GCs often lead to …