[HTML][HTML] Parkinson's disease: from pathogenesis to pharmacogenomics

R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …

[HTML][HTML] Genophenotypic factors and pharmacogenomics in adverse drug reactions

R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

[HTML][HTML] ChatGPT and the rise of generative AI: Threat to academic integrity?

DO Eke - Journal of Responsible Technology, 2023 - Elsevier
The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

The role of pharmacogenomics in adverse drug reactions

R Cacabelos, N Cacabelos, JC Carril - Expert Review of Clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Adverse drug reactions (ADRs) are a major health concern
worldwide. There are multiple causes of ADRs, some of which are preventable …

[HTML][HTML] Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible …

SM Elhusseiny, TS El-Mahdy, MF Awad, NS Elleboudy… - Molecules, 2021 - mdpi.com
In this study, we examined aqueous extracts of the edible mushrooms Pleurotus ostreatus
(oyster mushroom) and Lentinula edodes (shiitake mushroom). Proteome analysis was …

ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease

S Ismael, K Sakata, MP McDonald, FF Liao… - Neurochemistry …, 2021 - Elsevier
Although the exact etiology of Alzheimer's disease (AD) is poorly understood, experimental
and clinical evidences suggest the contribution of neuroinflammation in the pathogenesis of …

[HTML][HTML] Epigenetics of aging and Alzheimer's disease: Implications for pharmacogenomics and drug response

R Cacabelos, C Torrellas - International journal of molecular sciences, 2015 - mdpi.com
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA
regulation) is common in physiological and pathological conditions. Epigenetic alterations …

Acetylcholinesterase: a primary target for drugs and insecticides

S Thapa, M Lv, H Xu - Mini reviews in medicinal chemistry, 2017 - ingentaconnect.com
Background: Acetylcholinesterase is a serine hydrolase that terminates the action of the
neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Objective: The …

[HTML][HTML] Sirtuins in Alzheimer's disease: SIRT2-related genophenotypes and implications for pharmacoepigenetics

R Cacabelos, JC Carril, N Cacabelos… - International journal of …, 2019 - mdpi.com
Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with
important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular …

Metabolic disorder in Alzheimer's disease

MK Poddar, S Banerjee, A Chakraborty, D Dutta - Metabolic brain disease, 2021 - Springer
Abstract Alzheimer's disease (AD), a well known aging-induced neurodegenerative disease
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …