[HTML][HTML] Parkinson's disease: from pathogenesis to pharmacogenomics
R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
[HTML][HTML] Genophenotypic factors and pharmacogenomics in adverse drug reactions
R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …
illness in developed countries. ADRs show differential features depending upon genotype …
[HTML][HTML] ChatGPT and the rise of generative AI: Threat to academic integrity?
DO Eke - Journal of Responsible Technology, 2023 - Elsevier
The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …
systems and their possible impacts on Academic integrity. This paper provides an overview …
The role of pharmacogenomics in adverse drug reactions
R Cacabelos, N Cacabelos, JC Carril - Expert Review of Clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Adverse drug reactions (ADRs) are a major health concern
worldwide. There are multiple causes of ADRs, some of which are preventable …
worldwide. There are multiple causes of ADRs, some of which are preventable …
[HTML][HTML] Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible …
In this study, we examined aqueous extracts of the edible mushrooms Pleurotus ostreatus
(oyster mushroom) and Lentinula edodes (shiitake mushroom). Proteome analysis was …
(oyster mushroom) and Lentinula edodes (shiitake mushroom). Proteome analysis was …
ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease
Although the exact etiology of Alzheimer's disease (AD) is poorly understood, experimental
and clinical evidences suggest the contribution of neuroinflammation in the pathogenesis of …
and clinical evidences suggest the contribution of neuroinflammation in the pathogenesis of …
[HTML][HTML] Epigenetics of aging and Alzheimer's disease: Implications for pharmacogenomics and drug response
R Cacabelos, C Torrellas - International journal of molecular sciences, 2015 - mdpi.com
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA
regulation) is common in physiological and pathological conditions. Epigenetic alterations …
regulation) is common in physiological and pathological conditions. Epigenetic alterations …
Acetylcholinesterase: a primary target for drugs and insecticides
S Thapa, M Lv, H Xu - Mini reviews in medicinal chemistry, 2017 - ingentaconnect.com
Background: Acetylcholinesterase is a serine hydrolase that terminates the action of the
neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Objective: The …
neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Objective: The …
[HTML][HTML] Sirtuins in Alzheimer's disease: SIRT2-related genophenotypes and implications for pharmacoepigenetics
R Cacabelos, JC Carril, N Cacabelos… - International journal of …, 2019 - mdpi.com
Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with
important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular …
important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular …
Metabolic disorder in Alzheimer's disease
Abstract Alzheimer's disease (AD), a well known aging-induced neurodegenerative disease
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …