Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive
degenerative joint disorder, OA is characterized by cartilage damage, changes in the …

Osteoarthritis (OA) refers to a group of mechanically-induced joint disorders to which both
genetic and acquired factors contribute. Current pathophysiological concepts focus on OA …

In the past decades, considerable efforts have been made to propose experimental and
clinical treatments for articular cartilage defects. Yet, the problem of cartilage defects …

Increased vascular endothelial growth factor (VEGF) levels are associated with osteoarthritis
(OA) progression. Indeed, VEGF appears to be involved in OA‐specific pathologies …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause
significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and …

The role of subchondral bone in the pathogenesis of cartilage damage has likely been
underestimated. Subchondral bone is not only an important shock absorber, but it may also …

Background Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult
disability. There is no cure for OA and there is no effective treatment to stop its progression …

Over the past few decades, significant progress has been made with respect to new
concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the …

One promising strategy to reconstruct osteochondral defects relies on 3D bioprinted three-
zonal structures comprised of hyaline cartilage, calcified cartilage, and subchondral bone …