Bloodstream infections (BSIs) are frequent in ICU and is a prognostic factor of severe sepsis.
Community acquired BSIs usually due to susceptible bacteria should be clearly …

Delayed administration of active anti-infective therapy is associated with increased rates of
adverse events, mortality, and costs among sepsis patients. Inherent limitations of …

Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and
aggressive interventions are essential for improving clinical outcomes. There are a number …

Sepsis is a major cause of hospital death in the United States (US) 1 and is associated with
over 850,000 annual emergency department visits. 2 Despite advances in care, patients with …

The rise of infections caused by multi-resistant gram-negative bacilli (MR-GNB), which
includes carbapenems, represents one of the major current challenges worldwide. These …

Abstract Background Burkholderia cepacia complex (Bc c) are a group of multidrug-resistant
gram-negative bacteria rarely reported in patients without cystic fibrosis (CF) or …

Purpose Antibiotic de-escalation is promoted to limit prolonged exposure to broad-spectrum
antibiotics, but proof that it prevents the emergence of resistance is lacking. We evaluated …

This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in …

Mortality and morbidity in severe sepsis and septic shock remain high despite significant
advances in critical care. Efforts to improve outcome in septic conditions have focused on …

Clinical Question In patients with respiratory tract infection, is measurement of procalcitonin
to guide antibiotic prescriptions associated with reduced antibiotic exposure without …