[HTML][HTML] NTRK gene fusions as novel targets of cancer therapy across multiple tumour types
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …
[HTML][HTML] Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …
NTRK genes and have a role in the development and normal functioning of the nervous …
Safety and antitumor activity of the multitargeted pan-TRK, ROS1, and ALK inhibitor entrectinib: combined results from two phase I trials (ALKA-372-001 and …
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was
evaluated in two phase I studies in patients with advanced or metastatic solid tumors …
evaluated in two phase I studies in patients with advanced or metastatic solid tumors …
Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance
Structural gene rearrangements resulting in gene fusions are frequent events in solid
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
M Grieco, M Santoro, MT Berlingieri, RM Melillo… - Cell, 1990 - cell.com
We recently detected a novel activated oncogene by transfection analysis on NIH 3T3 cells
in five out of 20 primary human thyroid papillary carcinomas and in the available lymph node …
in five out of 20 primary human thyroid papillary carcinomas and in the available lymph node …
A review of NTRK fusions in cancer
CA Manea, DC Badiu, IC Ploscaru… - Annals of Medicine …, 2022 - journals.lww.com
The family of the neurotrophic tropomyosin kinase receptors (NTRK or TRK) is a part of the
transmembrane tyrosine kinases responsible for neuronal development. The members of …
transmembrane tyrosine kinases responsible for neuronal development. The members of …
The trk proto-oncogene encodes a receptor for nerve growth factor
R Klein, S Jing, V Nanduri, E O'Rourke, M Barbacid - Cell, 1991 - cell.com
Two classes of receptors with distinct affinities for nerve growth factor (NGF) have been
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …
Emerging Targeted Therapy for Tumors with NTRK Fusion Proteins
ES Kheder, DS Hong - Clinical Cancer Research, 2018 - AACR
The oncogenesis-promoting role of chromosomal rearrangements for several hematologic
and solid malignancies is well recognized. However, identifying targetable, actionable, and …
and solid malignancies is well recognized. However, identifying targetable, actionable, and …
Inhibiting TRK proteins in clinical cancer therapy
AM Lange, HW Lo - Cancers, 2018 - mdpi.com
Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been
identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase …
identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase …
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
D Soppet, E Escandon, J Maragos, DS Middlemas… - Cell, 1991 - cell.com
Neurotrophlc factors are essential for neuronal survival and function. Recent data have
demonstrated that the product of the tyrosine kinase frk protooncogene binds NGF and is a …
demonstrated that the product of the tyrosine kinase frk protooncogene binds NGF and is a …