Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

Severe persistent post-surgical pain (PPP) affects 2–10% of adults undergoing surgery, 1
corresponding to at least 140 000 patients per year presenting with disabling pain in the UK …

Abstract Persistent Post-Mastectomy Pain (PPMP) is a common condition that can follow
surgeries for breast cancer, the most common cancer in women. Because of the frequency of …

Converging lines of evidence suggest that the pathophysiology of pain is mediated to a
substantial degree via allostatic neuroadaptations in reward-and stress-related brain …

Intervertebral disc (IVD) herniation and degeneration contributes significantly to low back
pain (LBP), of which the molecular pathogenesis is not fully understood. Disc herniation may …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

Although certain risk factors can identify individuals who are most likely to develop chronic
pain, few interventions to prevent chronic pain have been identified. To facilitate the …