Background Millions of children have been born throughout the world thanks to ARTs, the
harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the …

Background Oxidative stress contributes to retina ganglion cells (RGCs) loss in variety of
ocular diseases, including ocular trauma, ocular vein occlusion, and glaucoma. Scavenging …

Short-chain fatty acids (SCFAs) exhibit anticancer activity in cellular and animal models of
colon cancer. Acetate, propionate, and butyrate are the three major SCFAs produced from …

Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal inflammatory disease,
mainly including Crohn's disease (CD) and ulcerative colitis (UC). In recent years, the …

Acute kidney injury (AKI) is a common critical illness in hospitalized patients, characterized
by a rapid decline in kidney function over a short period, which can seriously endanger the …

Due to its potent anti-tumor activity, well-investigated pharmacokinetic properties and safety
profile, disulfiram (DSF) has emerged as a promising candidate for drug repurposing in …

Kirsten rat sarcoma 2 viral oncogene homolog (Kras) is a proto-oncogene that encodes the
small GTPase transductor protein KRAS, which has previously been found to promote …

Parathyroid hormone is the main endocrine regulator of extracellular calcium and
phosphorus levels. Secondary hyperparathyroidism–induced endothelial dysfunction may …

Dual-specificity phosphatase 1 (DUSP1) is differentially expressed in cumulus cells of
different physiological states, but its specific function and mechanism of action remain …

Butyrate, a short-chain fatty acid, is predominantly produced by the decomposition of dietary
fiber in the colon. Recent studies have shown that sodium butyrate (NaB) can inhibit cell …