Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action

SA Brooks, PJ Blackshear - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

Bioinformatics and systems biology of the lipidome

S Subramaniam, E Fahy, S Gupta, M Sud… - Chemical …, 2011 - ACS Publications
Lipids play an important role in physiology and pathophysiology of living systems. Until a
few decades ago, the number of lipid molecules that were chemically characterized was a …

The biomolecular interaction network database and related tools 2005 update

C Alfarano, CE Andrade, K Anthony… - Nucleic acids …, 2005 - academic.oup.com
Abstract The Biomolecular Interaction Network Database (BIND)(http://bind. ca) archives
biomolecular interaction, reaction, complex and pathway information. Our aim is to curate …

Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody‐producing cell cultures

C Kontoravdi, SP Asprey… - Biotechnology …, 2005 - Wiley Online Library
Global sensitivity analysis (GSA) can be used to quantify the importance of model
parameters and their interactions with respect to model output. In this study, the Sobol …

Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types

D Song, D Cretoiu, M Zheng, M Qian… - Journal of cellular …, 2016 - Wiley Online Library
Telocytes (TC s) are new cellular entities of mesenchymal origin described almost
ubiquitously in human and mammalian organs (www. telocytes. com). Different subtypes of …

Muscle RING‐finger 2 and 3 maintain striated‐muscle structure and function

D Lodka, A Pahuja, C Geers‐Knörr… - Journal of Cachexia …, 2016 - Wiley Online Library
Abstract Background The Muscle‐specific RING‐finger (MuRF) protein family of E3 ubiquitin
ligases is important for maintenance of muscular structure and function. MuRF proteins …

Inferring protein–protein interactions through high-throughput interaction data from diverse organisms

Y Liu, N Liu, H Zhao - Bioinformatics, 2005 - academic.oup.com
Motivation: Identifying protein–protein interactions is critical for understanding cellular
processes. Because protein domains represent binding modules and are responsible for the …

A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection

RK Gurumurthy, AP Mäurer, N Machuy, S Hess… - Science …, 2010 - science.org
Chlamydiae are obligate intracellular bacterial pathogens that have a major effect on human
health. Because of their intimate association with their host, chlamydiae depend on various …

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

MA Hadders, M Agromayor, T Obita… - Proceedings of the …, 2012 - National Acad Sciences
The endosomal sorting complexes required for transport (ESCRT) proteins have a critical
function in abscission, the final separation of the daughter cells during cytokinesis. Here, we …

Two-dimensional annotation of genomes

B Palsson - Nature biotechnology, 2004 - nature.com
Figure 1 The chemical transformations between components on an annotated genome can
be represented as a matrix. Each state of a biological component is a row in the matrix, and …