Could gene therapy cure HIV?
Abstract The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …
The potential use of the CRISPR‐Cas system for HIV‐1 gene therapy
GDN Sanches-da-Silva, LFS Medeiros… - International journal of …, 2019 - Wiley Online Library
The HIV‐1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with
approximately 900000 deaths in 2017. The virus carrier can develop severe …
approximately 900000 deaths in 2017. The virus carrier can develop severe …
Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells
GN Llewellyn, E Seclén, S Wietgrefe, S Liu… - Journal of …, 2019 - Am Soc Microbiol
Combination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but
does not result in virus eradication or a cure. A major contributing factor is the long-term …
does not result in virus eradication or a cure. A major contributing factor is the long-term …
Safe CRISPR-cas9 inhibition of HIV-1 with high specificity and broad-spectrum activity by targeting LTR NF-κB binding sites
CH Chung, AG Allen, AJ Atkins, NT Sullivan… - … Therapy-Nucleic Acids, 2020 - cell.com
Viral latency of human immunodeficiency virus type 1 (HIV-1) has become a major hurdle to
a cure in the highly effective antiretroviral therapy (ART) era. The clustered regularly …
a cure in the highly effective antiretroviral therapy (ART) era. The clustered regularly …
CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector
CM Siegrist, SM Kinahan, T Settecerri, AC Greene… - Scientific reports, 2020 - nature.com
A vaccine for smallpox is no longer administered to the general public, and there is no
proven, safe treatment specific to poxvirus infections, leaving people susceptible to …
proven, safe treatment specific to poxvirus infections, leaving people susceptible to …
Application of CRISPR/Cas genomic editing tools for HIV therapy: toward precise modifications and multilevel protection
A Maslennikova, D Mazurov - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Although highly active antiretroviral therapy (HAART) can robustly control human
immunodeficiency virus (HIV) infection, the existence of latent HIV in a form of proviral DNA …
immunodeficiency virus (HIV) infection, the existence of latent HIV in a form of proviral DNA …
Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape
HIV-1 cure strategy by means of proviral knock-out using CRISPR-Cas9 has been
hampered by the emergence of viral resistance against the targeting guide RNA (gRNA) …
hampered by the emergence of viral resistance against the targeting guide RNA (gRNA) …
Expansion of the CRISPR/Cas genome-sculpting toolbox: Innovations, applications and challenges
The emergence of the versatile gene-editing technology using programmable sequence-
specific endonuclease system (CRISPR-Cas9) has instigated a major upheaval in …
specific endonuclease system (CRISPR-Cas9) has instigated a major upheaval in …
Assessment of anti-HIV-1 guide RNA efficacy in cells containing the viral target sequence, corresponding gRNA, and CRISPR/Cas9
AG Allen, CH Chung, SD Worrell, G Nwaozo… - Frontiers in genome …, 2023 - frontiersin.org
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 gene
editing system has been shown to be effective at inhibiting human immunodeficiency virus …
editing system has been shown to be effective at inhibiting human immunodeficiency virus …
On the road to a HIV cure: moving beyond Berlin and London
AIDS was first described as a new immunodeficiency syndrome in 1981. 1 The relatively
short history of human immunodeficiency virus (HIV) medicine is marked by major …
short history of human immunodeficiency virus (HIV) medicine is marked by major …