Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …

Bioconjugation reactions are critical to the modification of peptides and proteins, permitting
the introduction of biophysical probes onto proteins as well as drugs for use in antibody …

The increasing pressure for lithium resources from the electric vehicle and nuclear energy
industries means that new technologies to separate Mg2+ from Li+ from salt water are in …

Water soluble squaramide macrocycles (MSQs) display high sulfate binding affinities in
aqueous DMSO mixtures. The introduction of pyridine spacers into the macrocycles resulted …

Stimuli responsive anion transport is becoming an important aspect of supramolecular anion
recognition chemistry. Herein, we report the synthesis of a family of anion receptors that …

Simple, clean and fast photoconversion of aniline-derived squaramides was achieved by
flashlight illumination. UV irradiation enabled the photochemical squaramide ring-opening …

Supramolecular hydrogels with tunable properties have innovative applications in
biomedicine, catalysis, and materials chemistry. Minimalist low‐molecular‐weight …

DNA-encoded libraries (DELs) can be considered as one of the most powerful tools for the
discovery of small molecules of biological interest. However, the ability to access large DELs …

Herein we report the design, synthesis and assessment of the first example of a squaramide-
based self-immolative system triggered by an enzymatic reduction. We have proved that the …

Chagas Disease is caused by infection with the insect-transmitted protozoan Trypanosoma
cruzi and affects more than 10 million people. It is a paradigmatic example of a chronic …