The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …

Xenobiotic-induced liver injury is a clinically important etiology of hepatic disease that, if not
recognized, can lead to hepatic failure. In this article we discuss the mechanisms of …

There is mounting evidence to suggest that lean body mass (LBM) may be a better predictor
of drug dosage than either total bodyweight (TBW) or body surface area (BSA), although the …

In addition to differences in the pharmacodynamic response in the infant, the dose and the
pharmacokinetic processes acting upon that dose principally determine the efficacy and/or …

Dramatic developmental changes in the physiological and biochemical processes that
govern drug pharmacokinetics and pharmacodynamics occur during the first year of life …

Importance There is limited information on infant drug exposure via breastfeeding by
mothers who are receiving antiepileptic drug therapy. Objective To provide direct, objective …

A significant increase in the knowledge base in paediatric clinical pharmacology has
occurred over the past 2 decades and has largely been the result of important scientific and …

Very few studies have been carried out looking at how the effects of drugs and their toxicity
in humans change during their lifespan (developing and ageing). The purpose of this study …

Selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines are frequently used to
treat maternal depression during pregnancy, however the effect of increased serotonin …

Local anesthetic agents play a key role in the treatment and prevention of pain in children.
Although generally safe and effective, as with any pharmacologic agent, adverse effects may …