Resistance to quinoline antimalarials, especially to chloroquine and mefloquine has had a
major impact on the treatment of malaria worldwide. In the period since 2000, significant …

Chloroquine (CQ) has been the front line antimalarial drug due to its efficacy, low cost and
scanty side effects, until resistance has evolved. Although its use has been officially …

A series of 4-amino-7-chloroquinolines with dibenzylmethylamine (dibemethin) side chains
were shown to inhibit synthetic hemozoin formation. These compounds were equally active …

Background Prescription practices have been shown to influence the emergence of anti-
malarial drug resistance. Thus efforts in this study were devoted to evaluating the …

Using CATALYST, a three-dimensional QSAR pharmacophore model for chloroquine (CQ)-
resistance reversal was developed from a training set of 17 compounds. These included …

Malaria parasites continue to pose a concern. Drug resistance underlines the need for new
structural cores that, when combined with existing antimalarial frameworks, can partially re …

ABSTRACT A series of novel 10-N-substituted acridones, bearing alkyl side chains with
tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for …

Chemoresistance is a general health problem concerning infectious diseases and cancer
treatments. In this context, the worldwide dissemination of≪ pandrug≫ and≪ multidrug≫ …

For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-
aminoalkyl substitution was a minimum but insufficient structural feature associated with …

A series of 12 new dibemethin (N-benzyl-N-methyl-1-phenylmethanamine) derivatives
bearing an N-aminomethyl group attached to the one phenyl ring and an H, Cl, OCH3 or N …